Your brain mediates everything that you sense, feel, think, and do. The brain is incredibly complex - each cubic millimeter of your brain contains perhaps a hundred thousand cells, connected by a billion synapses, each operating with millisecond precision. We develop tools that enable the mapping of the molecules and wiring of the brain, the recording and control of its neural dynamics, and the repair of its dysfunction. We distribute our tools as freely as possible to the scientific community, and also apply them to the systematic analysis of brain computations, aiming to reveal the fundamental mechanisms of brain function, and yielding new, ground-truth oriented therapeutic strategies for neurological and psychiatric disorders.
News
- Nature Nanotechnology: A highly homogeneous polymer composed of tetrahedron-like monomers for high-isotropy expansion microscopy
- Congratulations to Andrew Payne and Dan Oran, for passing their PhD defenses
- Science: expansion sequencing: spatially precise in situ transcriptomics in intact biological systems
- Science: in situ genome sequencing resolves DNA sequence and structure in intact biological samples
- Cell: spatial multiplexing of fluorescent reporters for imaging signaling network dynamics
- Congrats to Evelyn Wong, for winning a Marshall Scholarship
- Methods in Molecular Biology: protocol for expansion microscopy of C. elegans
- Nature Biotechnology: RNA timestamps identify the age of single molecules in RNA sequencing
- Optica: sparse decomposition light-field microscopy for high speed imaging of neuronal activity
- bioRxiv: expansion revealing: decrowding proteins to unmask invisible brain nanostructures
- Congrats to Sam Rodriques, Rui Gao, and Or Shemesh, who accepted tenure-track faculty jobs
- Boyden elected to the National Academy of Sciences (MIT News)
- A Neurobiologist Thinks Big — and Small (Quanta Magazine)
- New Electrical Brain Stimulation Technique Shows Promise in Mice (New York Times)